Genotype-positive = Pathogenic/likely pathogenic (P/LP) variant on genetic testing deemed to be causal.
Genotype-negative: No P/LP variant on genetic testing.
VUS = Variant of uncertain significance on genetic testing (genotype-inconclusive).
We thank Chun-Po Steve Fan, Emily Somerset and Myriam Lafreniere-Roula (Ted Rogers Computational Program, Ted Rogers Centre for Heart Research, The Hospital for Sick Children, University Health Network) for their collaboration in the analysis, development and implementation of the risk calculator.
Miron A et al. A validated model for sudden cardiac death risk prediction in pediatric hypertrophic cardiomyopathy. Circulation 2020; 142(3): 217-229.